Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4021)
Related Products (4021)
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α-D-Glucosamine 1-phosphate
0 Imagesα-D-Glucosamine 1-phosphate is a glycosyl donor analog of Glc-1-P. α-D-Glucosamine 1-phosphate acts as a glycosyl donor to produce α(1→4)-linked glucosamine chains in the enzyme-catalyzed polymerization reaction mediated by thermostable α-glucan phosphorylase. α-D-Glucosamine 1-phosphate serves as a glycosyl donor analog to generate a pentasaccharide with a glucosamine residue at the non-reducing end in the maltotetraose glucosamination reaction catalyzed by potato α-glucan phosphorylase. α-D-Glucosamine 1-phosphate is used for the synthesis of amphiphilic block polysaccharides with pH-responsive assembly/disassembly properties.
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1-(2-Trifluoromethylphenyl)piperazine hydrochloride
0 ImagesCat. No.: HY-W714845CAS No.: 40160-26-71-(2-Trifluoromethylphenyl)piperazine hydrochloride is a piperazine.
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Kuwanon S
0 ImagesCat. No.: HY-N16130CAS No.: 100187-67-5Kuwanon S is a flavonoid compound that can be isolated from the root bark of Morus alba L. Kuwanon S is commonly used in organic synthesis and biochemistry experiments.
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Glycol salicylate (Standard)
0 ImagesGlycol salicylate (Standard) is the analytical standard of Glycol salicylate. This product is intended for research and analytical applications. Glycol salicylate is a derivative of salicylic acid and can be used to improve the aesthetic appearance of the skin.
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D-Cysteic acid
0 ImagesCat. No.: HY-W736050CAS No.: 35554-98-4D-Cysteic acid is a competitive inhibitor of the aspartate:alanine antiporter (AspT) from Tetragenococcus halophilus. For L-aspartate self-exchange, D-Cysteic acid has a Ki of 0.14 mM and an IC50 of 0.19 mM; for L-alanine self-exchange, it has a Ki of 5.0 mM and an IC50 of 9.0 mM. D-Cysteic acid occupies a distinct substrate-binding site within the substrate transport pathway of AspT, preventing the binding of natural substrates to the transporter. D-Cysteic acid can be used in studies related to substrate recognition and transport mechanisms of transporters.
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WAY-322454
0 ImagesWAY-322454 is an active molecule.
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Mardepodect precursor
0 ImagesCat. No.: HY-169773CAS No.: 871507-11-8Mardepodect precursor is the precursor of Mardepodect (HY-50098). Mardepodect precursor. Mardepodect is a potent, selective orally active, and brain-penetrant PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs.
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Omeprazole sulfone N-oxide
0 ImagesCat. No.: HY-138199CAS No.: 158812-85-2Omeprazole sulfone N-Oxide is an Omeprazole (HY-B0113) analog with binding affinity to Nilaparvata lugens choline acetyltransferase (ChAT).
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4'-Fluoro diazepam
0 ImagesCat. No.: HY-168358CAS No.: 52357-79-64'-Fluoro diazepam is a 1,4-benzodiazepine compound. 4'-Fluoro diazepam is structurally similar to Diazepam, but its has only minimal biological activity.
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7,7-Azo-3-α,12-α-dihydroxycholanic acid
0 ImagesCat. No.: HY-W706341CAS No.: 86992-52-17,7-Azo-3-α,12-α-dihydroxycholanic acid is a photoinactive (photopolymerization) derivative of Cholic acid (HY-N0324), and it has a relatively low affinity for high-density lipoprotein (HDL).
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Diethylene glycol cyclic phthalate
0 ImagesCat. No.: HY-W587858CAS No.: 13988-26-6Diethylene glycol bis phthalate is a phthalate ester and is used as plasticizers.
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1,3-Dimethylnaphthalene
0 ImagesCat. No.: HY-W087908CAS No.: 575-41-71,3-Dimethylnaphthalene is a Naphthalene (HY-Y0602) derivative. 1,3-Dimethylnaphthalene induces hatching of cod larvae.
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Asulacrine isethionate
0 ImagesCat. No.: HY-13552CAS No.: 80841-48-1Synonyms: CI-921 isethionate; NSC 343499 isethionateAsulacrine isethionate (CI-921 isethionate) is a derivative of Amsacrine (HY-13551), a Topoisomerase II inhibitor and an anticancer agent. Asulacrine isethionate binds to DNA via intercalation, forming stable complexes with long residence times at DNA sites. Asulacrine isethionate mediates DNA breakage and DNA-protein cross-linking. Asulacrine isethionate exhibits anticancer activity against leukemia or lung cancer. Asulacrine isethionate can be used in research related to breast cancer, lung cancer, mouse solid tumors and leukemia.
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2,5-DMMA
0 ImagesCat. No.: HY-172060CAS No.: 54687-43-32,5-DMMA is classified as a phenethylamine.
